ESPN’s 2010 Monday Night Football Schedule0
| Preseason | ||
| Date | Time (ET) | Teams |
| Aug. 12 | 8 p.m. | Carolina Panthers at Baltimore Ravens |
| Aug. 16 | 8 p.m. | New York Giants at New York Jets |
| Aug. 23 | 8 p.m. | Arizona Cardinals at Tennessee Titans |
| Aug. 26 | 8 p.m. | Indianapolis Colts at Green Bay Packers |
| Regular Season | ||
| Sept. 13 | 7 p.m. | Baltimore Ravens at New York Jets |
| 10:15 p.m. | San Diego Chargers at Kansas City Chiefs | |
| Sept. 20 | 8:30 p.m. | New Orleans Saints at San Francisco 49ers |
| Sept. 27 | 8:30 p.m. | Green Bay Packers at Chicago Bears |
| Oct. 4 | 8:30 p.m. | New England Patriots at Miami Dolphins |
| Oct. 11 | 8:30 p.m. | Minnesota Vikings at New York Jets |
| Oct. 18 | 8:30 p.m. | Tennessee Titans at Jacksonville Jaguars |
| Oct. 25 | 8:30 p.m. | New York Giants at Dallas Cowboys |
| Nov. 1 | 8:30 p.m. | Houston Texans at Indianapolis Colts |
| Nov. 8 | 8:30 p.m. | Pittsburgh Steelers at Cincinnati Bengals |
| Nov. 15 | 8:30 p.m. | Philadelphia Eagles at Washington Redskins |
| Nov. 22 | 8:30 p.m. | Denver Broncos at San Diego Chargers |
| Nov. 29 | 8:30 p.m. | San Francisco 49ers at Arizona Cardinals |
| Dec. 6 | 8:30 p.m. | New York Jets at New England Patriots |
| Dec. 13 | 8:30 p.m. | Baltimore Ravens at Houston Texans |
| Dec. 20 | 8:30 p.m. | Chicago Bears at Minnesota Vikings |
| Dec. 27 | 8:30 p.m. | New Orleans Saints at Atlanta Falcons |
